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The Myth of the Ageing Placenta


I am a doula and birth educator.

I also have a PhD in physiology of reproduction, and 20 years of research experience and I have a confession to make: I get REALLY irate when women get given poor quality evidence (or no evidence at all) in support of a recommendation for inducing labour.

Whether I’m wearing my doula hat, or my scientist hat, I have to admit to getting really fed up with the growing epidemic of induction of labour for dubious reasons. This article is going to explore one of the most common stated reasons for induction of labour at term : The idea that labour should be induced before a certain point in pregnancy is reached because the ‘older’ placenta is not as efficient.

I want to clarify one thing before we start: I am NOT anti induction, when it is justified by solid medical evidence and when a woman weighs up the evidence and decides that the risk of continuing the pregnancy is higher than the risk of inducing labour (like for example pre-eclampsia or reduced fetal movements, or when there are psychological reasons for the woman to choose to be induced).

Over the last 8 years, between teaching antenatal classes and supporting women, I have heard and witnessed hundreds of stories of induction, the majority of which ended up being traumatic for the mother.

In my area of work we often refer to this as the “car crash”, which goes something like this: 3 days of prostaglandin induction (often made more stressful because the woman cannot be with her family for much of the time), followed by 24 hours of syntocinon and a caesarean at the end for either fetal distress or “failure to progress” (if only women were told : We’re really sorry, we didn’t manage to get you into labour with our drugs, so now the only option is a cesarean, maybe women wouldn’t feel as traumatised as when they are labelled a failure. Language matters).

I have listened and held women (and their partners) as they told me of their upset, their grief, their disbelief, lack of preparation and their feelings of failure.

One of the top quoted reasons for inducing women when pregnancy goes beyond 41 weeks is the idea that the placenta somehow stops working after pregnancy reaches a certain number of weeks.

The implication is that the placenta has a sell by date, like a piece of meat in the supermarket.

Recently yet more papers have been published claiming as a fact that placentas “age”, “degrade” and “fail” in older mothers and after a certain number of weeks of pregnancy.

I don’t normally like to write solely about science stuff these days. I like to write about how I feel about issues, and stick a few references in for people who want to read them. I spent 20 years doing scientific research in the academic and industry setting. I’ve moved on from this, I find most of the scientific world too dry and frankly, too blinkered.

But I’m losing patience with this so-called science causing so much damage to women.

I was very concerned a few weeks ago to watch a heated debate on social media about this topic; seeing many of my colleagues being gaslighted into believing the so-called science by people who claim to have all the answers, using jargon that they do not understand.

I believe that my scientific background combined with my  experience as antenatal educator and doula gives me a unique, broad perspective on this topic.

So it’s time to put my scientific hat back on, analyse the papers in question, and offer my rather alternative interpretation of the current evidence, so that women and birth workers can make truly informed decisions, not one-sided ones based on the opinions of a few so-called experts whose views are based on their existing belief and opinion rather than a considered weighing-up of the evidence in this area.

I suggest you grab yourself a cup of tea, because this is going to be a long one!

Before I start I want to make an important point: even experts in a field often disagree with one another.

When I was working in the academic field during my PhD and 2 postdocs, working in a small niche area of biology research (clock genes, the genes which control rhythms, such as waking and sleeping), I published in fairly high ranking scientific papers, and became quickly perceived as an expert in my field. This led me to be invited as a guest speaker at conferences. I remember arguing until I was blue in the face about the interpretation of certain data with other experts in the field. It was done passionately, but it was entertaining, good humoured and fun. It happened because, as I will explain below, good scientists understand that science isn’t black and white.

The conversations I see on social media about this research aren’t like this. I see experts pretending to have all the answers, presenting themselves as the only ones who have all the knowledge, and frankly bamboozling and bullying non scientists with jargon.

In this particular case, they take the moral high ground, presenting themselves as saviours, as if stillbirths could be guaranteed to be prevented if only we induced all women at a certain number of weeks of pregnancy. They attack other people whose views are different, even when these people are equally or more qualified and hold PhDs in relevant fields.

This isn’t right. This harms women, and this harms the people who are supporting them too.

Even in science, things are never black and white. Nothing is guaranteed. There are many shades of grey. And pretending that things are this way isn’t science, it is delusion, and it is treating science as a dogma. If you want to find out more about this way of thinking, watch Cambridge scientist Dr Rupert Sheldrake’s banned TED talk on the topic.

Now that’s out of the way, back to the subject at hand: do placentas really age? Do they stop functioning correctly towards the end of pregnancy? And most importantly, are they solely responsible for the (let’s remember, tiny) rise in stillbirth towards the end of pregnancy? These are the assumptions that currently underpin our induction policies.

I feel I need to explain first that the risk of increased stillbirth at term, which is the main reason behind induction policy, is actually very small, rising from about 0.1% (1 in a 1000) at 40-41 weeks, to about 0.3% (3 in a 1000) at 42 weeks and about 0.5% (5 in a 1000) at 43 weeks (from this paper). The Cochrane review on induction beyond term , found that induction before 42 weeks reduced the risk of perinatal death from 0.3% to 0.03%, and that the authors of the review concluded that:

” A policy of labour induction compared with expectant management is associated with fewer perinatal deaths and fewer caesarean sections. Some infant morbidities such as meconium aspiration syndrome were also reduced with a policy of post-term labour induction although no significant differences in the rate of NICU admission were seen. However, the absolute risk of perinatal death is small. Women should be appropriately counselled in order to make an informed choice between scheduled induction for a post-term pregnancy or monitoring without induction (or delayed induction).”

In practice I almost never see the part highlighted in bold being presented as an option to women (read my previous blog about it here)

I would like to quote the seminal paper by the late Dr Fox “Aging of the placenta

” A review of the available evidence indicates that the placenta does not undergo a true aging change during pregnancy. There is, in fact, no logical reason for believing that the placenta, which is a fetal organ, should age while the other fetal organs do not: the situation in which an individual organ ages within an organism that is not aged is one which does not occur in any biological system. The persisting belief in placental aging has been based on a confusion between morphological maturation and differentiation and aging, a failure to appreciate the functional resources of the organ, and an uncritical acceptance of the overly facile concept of “placental insufficiency” as a cause of increased perinatal mortality.”

Whilst I am fully aware that this paper is dated, having being published in 1997, and that much more research has been carried out since, I still believe his conclusion stands, the last sentence in particular.

I’ve heard many maternity care providers coerce expectant mothers to accept induction (remember, if you feel coerced, this isn’t consent) to the cries of “your placenta is failing right now”. Yet, even today, we do not know what accounts for the tiny rise in neonatal mortality after 40 weeks.

There seems to be a strong desire to prove the causality between placental aging and the increase in stillbirth and this desire is guided by a positive drive, which is to reduce stillbirth.

I empathise with this drive better than you know, because my younger brother was stillborn so I fully understand the devastating effects the death of a new baby has on a family.

But for the moment it’s just this: a theory.

And anyone can invent a theory about anything, but that doesn’t make it true.

We need to find a balance between the real statistics and women’s wishes for a positive birth experience. Because there is no doubt from the evidence in this area that, as long as mother and baby are well, it is better for all involved for labour to start on its own.

Because we mustn’t forget that inductions can be very traumatic for women and they can cause fetal distress in babies.

It’s quite simple, really: let the mothers decide what they want. And for this, they need real facts and numbers, not emotive coercion.

First, a bit of history

How did the whole concept of placental failure ever come about?

In her book “Inducing labour, making informed decisions” , Dr Sara Wickham explains that this theory came about first via the work of Ballantyne who described a wasting condition of the newborn in 1902, followed by Runge in 1958 who coined the term placental insufficiency. This became known as the Ballantyne-Runge syndrome, and led to the assumption of a relationship between the length of pregnancy and placental failure.

Dr Wickham goes on to explain that this theory has never been proven and that there is no evidence behind it. She explains that, while we know that some women’s placentas do sometimes fail to provide sufficient nutrients for their baby, this doesn’t mean that all women’s placentas routinely fail at a certain point in time.  Further evidence of how much those who are challenging this theory really do care about the wellbeing of babies can be seen where Dr Wickham notes in her talks that the concern is not just about preventing unnecessary inductions for women who do not need them. By trying to make standardised, population-level recommendations (or a ‘one size fits all’ approach), we not only lead many women to have inductions that they do not need, but we may also fail to identify and help the small number of babies who truly do need help but at a point earlier than the current population-level cut-off point for induction.

Even in the papers claiming that there is a relationship between the length of pregnancy and the state of the placenta, when you dig into them, the conclusion reached is always that there is a “possible link” rather than a proven one.

And as I explained before, experts in the field do not agree with one another. In her book “Why induction matters“, Dr Rachel Reed quotes a couple of prominent papers, in particular a paper by Maiti et al which claims a direct link between placental aging and stillbirth, and a paper by Mazzurato et al ” Guidelines for the management of postterm pregnancy” which states that:

Although the fetal, maternal and neonatal risks increase beyond 41 weeks, there is no conclusive evidence that prolongation of pregnancy, per se, is the major risk factor. Other specific risk factors for adverse outcomes have been identified, the most important of which are restricted fetal growth and fetal malformations. In order to prevent PT (Post term) and associated complications routine induction before 42 weeks has been proposed. There is no conclusive evidence that this policy improves fetal, maternal and neonatal outcomes as compared to expectant management.”

The nitty gritty of the arguments behind the aging placenta theory

Some of the technical terms I see bandied around a lot, and which bamboozle many of my colleagues because they do not understand their meaning, are morphological changes in the placenta such as apoptosis, autophagy, syncytial knots, reduction in telomere length and so on. In many papers, the authors claim that these are key features of aging, and observed in post-term placentas.

Yet there is more than one interpretation of these morphological changes so often lauded as proof of a placental ‘sell-by date’. They do not automatically mean that there is a problem. In many ways, our understanding of this area is in its infancy, and we would do better to take a position of scientific humility while we try to determine the meaning of these findings.

One of the most striking examples of a study which makes suggestions that aging of the placenta at term is a fait accompli is this study, with its sensational title: “Evidence that fetal death is associated with placental aging” by Maiti et al.

I find one of the statements in this paper extremely concerning:

” The known exponential increase in unexplained intrauterine death that occurs >38 weeks of gestation may therefore be a consequence of aging of the placenta and decreasing ability to adequately supply the increasing needs of the growing fetus. This knowledge may impact on obstetric practice to ensure infants are born before the placenta ages to the point of critical failure

I fear such a statement will be used to pressure yet more women into being induced earlier, without any concerns for their personal decision or well being. And yet, as I will keep saying, this is still an unproven theory and different experts have different opinions about whether it is true or not. The medical profession is based on the tenet of ‘first do no harm’ and my understanding is that this means that we should not intervene unless we have good evidence to support doing so.

I will go through clarifying the differential interpretation of some of the changes observed in the placenta.

One of the changes they observe in this paper is decreased autophagy. Autophagy is a kind of cellular recycling system. The authors infer that these changes are a proof of aging. Yes, autophagy decrease has been associated with aging in some studies. Some other authors, however, are suggesting that the reduction in autophagy in the placenta may be part of the process that actually starts labour and so it may be a normal and important part of a physiological process rather than a sign that something is ‘wrong’.

Another placental change, quoted in the paper by Maiti cited above, is apoptosis (also known as programmed cell death). Apoptosis isn’t just a proof of senescence (aging). Apoptosis also happens during fetal development and during adolescence. It is as much as sign of change as it is a sign of ageing, and of course change and growth are very important at this time; the whole point of pregnancy is that the baby grows and changes

“The role of apoptosis in normal physiology is as significant as that of its counterpart, mitosis. It demonstrates a complementary but opposite role to mitosis and cell proliferation in the regulation of various cell populations. It is estimated that to maintain homeostasis in the adult human body, around 10 billion cells are made each day just to balance those dying by apoptosis (Renehan et al., 2001). And that number can increase significantly when there is increased apoptosis during normal development and aging or during disease.”

And during pregnancy

“Trophoblast apoptosis is a physiologic event in normal pregnancy, increases with advancing gestational age and is higher in post- term pregnancies and therefore is considered as a normal process in the development and ageing of the placenta.”

Again and again we see that the processes which are claimed by some to be evidence of aging could also be interpreted to be signs of the normal growth and change which are the very function of pregnancy.

Syncytial knots (SNAs, an accumulation of cell nuclei (the centre of cells) inside placenta cells) are another change quoted as a proof of ageing:

” SNAs may form to structurally reinforce the placenta and minimise damage from shear stresses or other mechanical sources, reduce the proportion of nuclei in highly active vasculo-syncytial membranes or result from cell turnover in the placenta without an apoptotic trigger or shedding process. Ultimately, a better understanding of the processes leading to SNA formation will give insight into their significance in pregnancy complications.”

So again, what we are seeing could just as well be an adaptation rather than a sign of ageing.

Telomere length :

“Telomeres, the DNA–protein structures located at the ends of chromosomes, have been proposed to act as a biomarker of aging. In this review, the human evidence that telomere length is a biomarker of aging is evaluated. Although telomere length is implicated in cellular aging, the evidence suggesting telomere length is a biomarker of aging in humans is equivocal. More studies examining the relationships between telomere length and mortality and with measures that decline with “normal” aging in community samples are required. These studies would benefit from longitudinal measures of both telomere length and aging-related parameters.”

In this paper called “Questioning causal involvement of telomeres in aging” the authors state:

“Multiple studies have demonstrated that telomere length predicts mortality and that telomeres shorten with age. Although rarely acknowledged these associations do not dictate causality. In addition, the causality hypothesis assumes that there is a critical telomere length at which senescence is induced. This generates the prediction that variance in telomere length decreases with age. In contrast, using meta-analysis of human data, I find no such decline. Inferring the causal involvement of telomeres in aging from current knowledge is therefore speculative and could hinder scientific progress.”

What I find of particular interest, is that the authors of this paper also speculate that these cellular changes may form part of what starts labour:

” Placental senescence raises several important questions that need to be addressed experimentally. While fusion-induced senescence appears to be required for syncytiotrophoblast formation, it is likely that senescence of both fetal tissues and the maternal decidua play at least a part in determining timing of labour onset”

So what if what is seen in the placenta and interpreted as a sign of aging, are in fact normal, healthy changes, which are a sign of healthy growth and development and which may also play a role in the start of labour?

Another “older” sign of placental aging is calcifications. I’ve been guilty myself of believing people who told me it was a sign of ageing and it was good that the baby had been born because the placenta was “old”. I recently came across this blog (which has published references to back up all its claims):

So while calcification of a placenta at term – around 39-42 weeks is part of the normal appearance of a full-term placenta and has no clinical significance in a healthy pregnancy, the appearance of significant calcification earlier in pregnancy is associated with risks to both the mother and baby. Just like we would be concerned about a very young person with wrinkles – it could be a sign of something significant happening (…) So, in essence, when a mother is healthy and full term, calcification and infarcts are normal features of a healthy placenta – just like your healthy mother has some wrinkles and a few grey hairs. 

Yet another myth blown out of the water.

In conclusion, whilst there is evidence of cellular changes in the placenta throughout the course of pregnancy, there still isn’t any solid evidence to prove that it is indeed aging rather than an adaptation, or that these changes are truly accountable for the tiny rise in stillbirth when pregnancies continue beyond 42 weeks.

The concept of the aging placenta is still just that, a theory. Unfortunately the majority of the publications cited in this post fail to acknowledge this, and take this theory as proven.

What worries me even more, is that no consultation of women’s view on the induction process usually takes place, and these publications will form the basis of the new NICE guidelines, then the local hospital guidelines, and therefore more and more women will be induced needlessly, and have negative or traumatising experiences.

This is underpinning a current trend towards inducing women even earlier, at 39 weeks instead of the current 41 to 42 weeks.

Evidence based birth has produced an excellent review of the literature on this topic.

I hope that reading this blog will help women and their supporters make informed decisions.

I also would like to encourage scientists and policy makers to stay curious about the wider picture and to engage more with pregnant women and their views on the induction process.

I am grateful to Maddie McMahon for editing this blog

If this resonates with you and you would like to work with me, head over here if you’re an expectant or new mum, or here if you are a birthworker.

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  1. Tracy on December 4, 2018 at 9:39 pm

    Thank you Sophie for this article ! Sadly I hear of this coercive rationale for IOL alot- I have looked at the ‘evidence and also came up with nothing robust- interestingly I was listening to Rupert Sheldrake and Graham Hancock who have both been castigated by TED as pseudo scientists by their peers ! You may of heard of a podcast by Andrew Tsakiris called Skeptico on you tube it’s worth a watch for challenging dogmatic science .

  2. Michelle on December 4, 2018 at 11:21 pm

    Thank you Sophie (and Maddy) for taking the time to research, write (edit) and share this very much needed blog.
    Here’s hoping it can be a catalyst for change.

  3. Jenny on December 5, 2018 at 7:31 am

    Thank you Sophie! A very well written and referenced blog looking at the much wider issues affecting pregnant women as they approach term.
    It is so important that women are able to understand the absolute risks that relate to them personally and make informed decisions about their pregnancy.

  4. Sara Wickham on December 5, 2018 at 8:40 am

    Great post Sophie, thank you. I couldn’t agree with you more about the importance of (well mannered) scientific debate, and you have showed beautifully how research findings can be interpreted in different ways. In medicine there has always been a tenet of ‘first do no harm’, which means we should not suggest or recommend intervention unless we have good reason to do so, or good evidence that it will be more beneficial to interfere than to let things run their own course. And even then it is still, of course, the woman’s decision as to whether she wants intervention or not. It is great to have this clear analysis of how there is a lack of evidence to support the myth of the aging placenta. Thanks for your work 🙂

  5. Sammie on December 5, 2018 at 11:05 am

    Thank you for such an informative blog.
    I am gutted to read that calcification is actually normal. I waited til I 26 days post dates (12 days post term), but eventually agreed to induction as they said my placenta was thin and extremely calcified. It had been absolutely fine up until that point…

  6. Tara on December 5, 2018 at 1:15 pm

    Wonderful post! I’m another doula and childbirth educator who’s particularly interested in this topic because of my own birth history (5 “overdue” babies between 41+2 and 44 weeks) and the many tough inductions, often without clear medical indication, I’ve seen in practice. I’m always looking for more information to share with my class and clients.

  7. Jason H Collins MD,MSCR on December 6, 2018 at 1:23 am

    Placental function will be better understood with Fetal MRI/O2 studies now being published . Past terminology will be replaced based on future studies which have already shown differences in vascular structure and O2 delivery over time. There are also molecular and micro array (genetic) differences being reported.

    Jason H Collins MD, MSCR

    • sophie on December 6, 2018 at 9:21 am

      Thank you for your comment, Jason. Could you explain what point you are trying to make with your statement?

    • Joe Watling on February 4, 2019 at 2:25 pm

      Are you able to share these future studies? As per the article is is always great to have evidence based scientific studies that we can read and make informed decisions with the facts presented.

  8. Katie on December 6, 2018 at 6:17 pm

    Thank you Sophie for this fantastic analysis. The obstetricians I encounter seem to have a “better out than in” attitude to virtually every woman they meet these days. They are quick in recommending induction at 39 weeks, without even discussing the potential risks of doing so, or weighing that against possible benefit of waiting for labour. They seem oblivious to the real short and long term effect this has on maternal physical and mental health, as if this is totally irrelevant. So many times I hear women devastated because they have had their birth plans obliterated and all for totally non evidence based reasons. What I can do is hold space for her sadness, present her with the information so she can make her own choice, witness the car crash, and do all I can to minimise the damage by bringing calm, loving care.

    • CJ on April 15, 2019 at 9:30 pm

      A friend of mine she was told her placenta won’t carry her babies pasted 37 weeks. I think due to a stillborn now has baby # 2 & #3 she’s wanting to have a vaginal birth but again they advice her to have it before then. I understand she’s ok with that however would like a vaginal birth where possible so trying to assist her where ever best I can?.

      • sophie on April 22, 2019 at 10:27 am

        Hi Katie, it’s always complex to manage this kind of situation, because for the mother to make a truly informed decision she needs to have all the facts, and be supported by health professionals to make the right choice for her. Some mums have found books such as “what’s right for me” by Dr Sara Wickham, as well as “inducing labour” by the same author, or “why induction matters” by Dr Rachel Reed very helpful in these situations. The birthrights website is a very useful resource too and so is the AIMS one

  9. Vicki Youdan on December 6, 2018 at 10:32 pm

    Thank you so much for this Sophie. I’ve learned so much here today. And will continue to read your work.
    I’m a psychologist too, who’s gravitated to the world of birth over the past few years and I now teach hypnobirthing.
    Part of my work involves presenting up to date information to support parents in making informed choices, such as when some (including me in my own pregnancy) decide to decline induction purely for post dates.
    I’ve been reading the latest MBRACE figures for this.. I was just wondering what your thoughts are on those figures and if you chose not to quote them within this, instead choosing the Cochran figures. And what your thoughts were regarding that choice? Which would you consider most accurate? If that’s the right way to put it?
    I’m really keen to ensure I’m best informed and given this piece has taught me so much, I hope you don’t mind me asking your opinion on a little more?
    With very best wishes,


  10. Alex Heazell on December 8, 2018 at 11:02 pm

    Hi Sophie, this is an interesting blog, but I think omits a significant amount of relevant literature (which is fine, it’s not meant to be a systematic or scoping review). I think there is growing evidence regarding the role of placental dysfunction in stillbirth and we’ve done a series of studies in mothers over the age of 40 which showed that the placenta was different to women 4 million births found increases in preeclampsia, placental abruption, fetal growth restriction and preterm birth. Placental dysfunction is a feature of the first three conditions. In my view women should at least be offered additional screening for FGR if they possess important risk factors for the condition.
    I think that Gordon Smith’s work with the 35-39 study and the more recent analysis of induction of labour which generates a “number needed to treat” is really helpful, and we can counsel women that induction of labour does reduce perinatal mortality, but the NNT is large (>1 in 600 for women >35 years of age) although there is no increase in Caesarean birth rate.

  11. Margaret Jowitt on January 17, 2019 at 10:30 am

    Thanks for a really interesting read (and the link to Rupert Sheldrake’s TED talk – another book I have to buy)! I just wanted to point out that the perinatal mortality rates as shown by the Confidential Enquiries – CEMACH, CESDI, CMACE, MMBRACE have consistently shown a REDUCTION in stillbirth and neonatal death at 42 weeks ever since 2004. The rates were analysed by week of gestation only for 2 years and for one of these years there was indeed a very slight rise at 41 weeks only to go down again at 42 weeks. Now they just lump 37-41 together and don’t analyse (or at least don’t publish) by week of gestation – except 42+ is ALWAYS lowest of all weeks from 23 onwards. The real problem seems to be deaths in utero before the start of labour (what MMBRACE calls antepartum stillbirth) and it is these that IOL is seeking to reduce. I would argue that we cannot avoid risk altogether but the risk of induction – particularly if the fetus is already stressed – is probably about equal to the risk of death in utero at some time in the future, so NICE is right, it should be the woman’s choice, or, as you say, only for actual proven problems such as preeclampsia, reduced fetal movements, (?)maternal intuition. I think the figures on neonatal death bear out this reading of the figures – they tend to follow the (downward) line of mortality rate with time – and yet these fetuses did not suffer death in utero as they were born alive. We need MMBRACE to record stillbirth and neonatal death by mode of onset of labour to get a better picture. I also think that a fetus proved to be under stress should not be put through the additional stress of labour but that CS should be offered instead. We could also do with individual units auditing the outcome of induced labours because of course the mortality figures do not report on damaged babies who survive.

  12. […] who as a scientist and birth educator has also written eloquently on this subject Check out this blog on induction […]

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